Jnk1 (MAPK8) Monoclonal Antibody (2C6)

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Description	Size	Catalog#	Price	Quantity
Jnk1 (MAPK8) Monoclonal Antibody (2C6)	100 無	905-894	$230.00

Background

JNK1 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK1 is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of JNK1 by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. JNK1 is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of JNK1 gene suggested that it play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Table of Abbreviations

Applications
WB

Species Reactivity
H

Isotype
IgG1

Clone
2C6

Purification
Protein G Affinity

Immunogen
Recombinant protein expressed in E.coli corresponding to amino acids 1-384 of human JNK1

Host
Mouse

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

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Citations
Launch Citation Database

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Jnk1 (MAPK8) Monoclonal Antibody (2C6)